Nanoaggregate embedded beads conjugated to single domain...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 17/00 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 17/14 (2006.01) G01N 21/65 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2744384

A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological or environmental samples using Raman spectroscopy.

L'invention porte sur une bille incluse dans un nanoagrégat formée à partir d'un cur interne comprenant des nanoparticules métalliques et des molécules rapporteurs actives en Raman, une enveloppe externe et des anticorps à un seul domaine pour cibler la bille sur une cible spécifique. La bille incluse dans un nanoagrégat peut être utilisée dans des procédés pour détecter des analytes ou pathogènes dans des échantillons biologiques ou environnementaux à l'aide de la spectroscopie Raman.

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