Nanoassembled complexes of nucleic acids, avidin and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 31/4188 (2006.01)

Patent

CA 2691677

The present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high--affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or partially the nucleus itself. The nanocomplexes obtained have been shown to be stable in aqueous solutions and to have nanoparticle features. In addition, the nano-complexes have shown characteristics useful for use in biotechnological field and in nanomedicine.

La présente invention concerne de nouveaux complexes nano-assemblés constitués d'un noyau central formé par une interaction à haute affinité des acides nucléiques et de l'avidine, ledit noyau étant stabilisé dans des solutions aqueuses, même dans du sérum physiologique, et protégé d'autres interactions indésirables non spécifiques au moyen d'agents polymères adaptés capables de masquer totalement ou partiellement le noyau proprement dit. Les nanocomplexes obtenus se sont avérés très stables dans les solutions aqueuses et avoir des caractéristiques de nanoparticules. De plus, les nanocomplexes ont montré des caractéristiques utiles à une utilisation dans le domaine biotechnologique et en nanomédecine.

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