Nanobodies tm and polypeptides against egfr and igf-ir

Details Nanobodies tm and polypeptides against egfr and igf-ir Nanobodies tm and polypeptides against egfr and igf-ir

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/563 (2006.01) G01N 33/566 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2624781

The invention relates to polypeptides and Nanobodies against Epidermal Growth Factor Receptor (EGFR) and/or Insulin Growth Factor-I Receptor (IGF-IR). The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such Nanobodies, polypeptides, nucleic acids and/or host cells; and to uses of such Nanobodies, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

L'invention concerne des polypeptides et des Nanobodies ("nanocorps") dirigés contre le récepteur du facteur de croissance épidermique (EGFR) et/ou le récepteur du facteur de croissance de l'insuline de type 1 (IGF-1R). L'invention concerne également des acides nucléiques codant pour ces Nanobodies et ces polypeptides, des procédés de préparation de ces Nanobodies et polypeptides, des cellules hôtes exprimant ou pouvant exprimer ces Nanobodies ou polypeptides, des compositions, et notamment des compositions pharmaceutiques, renfermant ces Nanobodies, polypeptides, acides nucléiques et/ou cellules hôtes, ainsi que les utilisations desdit(e)s Nanobodies, polypeptides, acides nucléiques, cellules hôtes et/ou compositions, notamment à des fins prophylactiques, thérapeutiques ou diagnostiques.

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