Nanocarrier and nanogel compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/10 (2006.01) A61K 31/704 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2720474

Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.

L'invention concerne de nouvelles classes de matières à base de poly(oxyde d'alkylène) à plusieurs bras comprenant des nanosupports de PEG, des particules de nanogel et des particules de nanogel agrégées. Ces classes de compositions peuvent être associées avec des agents thérapeutiques et des fractions de ciblage, ou des agents augmentant la visibilité, et peuvent avoir une structure de surface modifiée. Dans certains modes de réalisation, les matières à base PEG peuvent être réalisées pour fournir des charges de médicament relativement élevées avec une solubilité améliorée et une administration ciblée améliorée.

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