Nanocomposite materials based on metallic nanoparticles...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 5/08 (2006.01) A61K 33/24 (2006.01) A61K 47/36 (2006.01) A61P 31/04 (2006.01) C08K 3/08 (2006.01) C08K 7/18 (2006.01)

Patent

CA 2731390

The present invention provides nanocomposite systems made of metallic nanoparticles stabilized with branched cationic polysaccharides, in particular alditolic or aldonic mono- and oligo- saccharidic derivatives of chitosan, and their preparation obtainable with aqueous solutions of these polysaccharides in the presence or absence of reducing agents. The peculiar chemical and physical-chemical features of these polysaccharides allow to form metallic nanoparticles homogeneously dispersed in the polysaccharidic matrix and an effective stabilization thereof. The properties associated with the nanometric dimensions and the presence of biological signals on polymeric chains may be exploited in applications with antimicrobial activities and of molecular biosensors.

La présente invention concerne des systèmes nanocomposites fabriqués à partir de nanoparticules métalliques stabilisées avec des polysaccharides cationiques ramifiés, en particulier des dérivés oligosaccharides et monosaccharides alditoliques ou aldoniques de chitosane, et leur préparation pouvant être obtenue avec des solutions aqueuses de ces polysaccharides en présence ou en l'absence d'agents réducteurs. Les caractéristiques chimiques et physico-chimiques particulières de ces polysaccharides permettent de former des nanoparticules métalliques dispersées de manière homogène dans la matrice polysaccharide et une stabilisation efficace de celles-ci. Les propriétés associées aux dimensions nanométriques et à la présence de signaux biologiques sur les chaînes polymères peuvent être exploitées dans des applications avec des activités antimicrobiennes et de biocapteurs moléculaires.

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