Nanoerythrosome as bioactive agent carrier

Details Nanoerythrosome as bioactive agent carrier Nanoerythrosome as bioactive agent carrier

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/51 (2006.01) A61K 35/18 (2006.01) A61K 47/46 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/12 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2150617

Carriers for pharmacologic agents comprise nanoerythrosomes, which are vesicles prepared by the extrusion of red blood cell ghosts, the average diameter of these vesicles is 0.1 µm; the daunorubicin was covalently linked to nanoerythrosomes and the cytotoxicity of daunorubicin conjugated to nanoerythrosomes was assessed on P388D1 cell line; the results indicated that the cytotoxicity of conjugated daunorubicin was higher than the free daunorubicin, similar results were observed on CDF1 mice bearing grafted P388D1 leukemia tumors; daunorubicin- nanoerythrosome conjugates had a higher antineoplastic activity than the free bioactive agent.

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