Nanofibers with high enzyme loading for highly sensitive...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 11/08 (2006.01) B82Y 15/00 (2011.01) A61B 5/00 (2006.01) C12N 9/00 (2006.01) C12N 9/04 (2006.01) C12Q 1/00 (2006.01) C12Q 1/32 (2006.01) G01N 33/487 (2006.01) G01N 27/416 (2006.01) G01N 33/66 (2006.01)

Patent

CA 2696783

The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent- based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.

L'invention concerne des nanofibres à charges d'enzyme élevées et des procédés utilisés dans leur fabrication, ces nanofibres étant utilisées en tant que nouvelle classe de biocapteurs ultra-sensibles et ultra-stables permettant de surveiller le glucose à des niveaux très bas. Ces biocapteurs, comprenant des matières enzymatiques de nanofibres fabriquées à partir de systèmes d'enzyme polymère à base de solvant organique, peuvent être utilisés efficacement dans des applications de biodétection transdermique non invasive.

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