Nanofilament scaffold for tissue regeneration

Details Nanofilament scaffold for tissue regeneration Nanofilament scaffold for tissue regeneration

A - Human Necessities

61

F

A61F 2/02 (2006.01)

Patent

CA 2599946

A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75 % of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.

L'invention porte sur un squelette pour la régénération de tissus. Dans un mode de réalisation préféré, le squelette peut être implanté dans un patient ayant besoin d'une régénération des nerfs ou d'autres tissus et comprend une structure qui est dotée d'une pluralité de nanofibres orientées dans le sens uniaxial et constituées d'au moins un polymère synthétique. De préférence, au moins 75 % des nanofibres sont orientés à 20 degrés du sens uniaxial. Ce squelette fournit de manière avantageuse des signaux de régénération des cellules et des tissus, vraisemblablement par imitation de la stratégie naturelle consistant à utiliser des structure filamenteuses au cours du développement et de la régénération.

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