Nanoparticle and polymer formulations for thyroid hormone...

A - Human Necessities – 61 – K

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A61K 31/192 (2006.01) A61K 9/51 (2006.01) A61P 35/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2673133

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone antagonist to inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone antagonists, are also disclosed.

La présente invention concerne les procédés de traitement des sujets avec des conditions associées à l'angiogénèse y compris l'administration d'une quantité effective d'une forme nanoparticulaire polymérique d'une agoniste, d'un agoniste partiel ou d'un antagoniste de l'hormone thyroïde pour promouvoir ou inhiber l'angiogénèse dans le sujet. Les compositions des formes polymériques de l'hormone thyroïde ou les analogues de l'hormone thyroïde sont également décrits.

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