Nanoparticle and polymer formulations for thyroid hormone...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/765 (2006.01) A61K 31/78 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2648243

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

L'invention concerne des procédés de traitement de sujets souffrant de maladies associées à l'angiogenèse, lesdits procédés comprenant l'administration d'une quantité efficace d'une forme nanoparticule polymère d'un agoniste, d'un agoniste partiel ou d'un antagoniste de l'hormone thyroïdienne afin de favoriser ou d'inhiber l'angiogenèse chez le sujet. L'invention concerne également des formes polymères de l'hormone thyroïdienne ou d'analogues de l'hormone thyroïdienne.

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