Nanoparticle based stabilization of ir fluorescent dyes

Details Nanoparticle based stabilization of ir fluorescent dyes Nanoparticle based stabilization of ir fluorescent dyes

A - Human Necessities

61

B

A61B 10/00 (2006.01) B32B 5/16 (2006.01) G01N 33/544 (2006.01)

Patent

CA 2516116

This invention relates to a highly effective nanoparticle system for stabilizing near-infrared (near-IR) fluorescent dyes such as indocyanine (ICG) in order to enhance the dye's utility for biomedical application. This invention further relates to nanoparticles comprised of biodegradable polymer materials such as poly(dl-lactide-co-glycolide)(PLGA). The invention also relates to methods of preparing the nanoparticle-entrapped dyes, as well as methods for using them in bioimaging, diagnosis, and treatment of disease. The present invention also relates to compositions and kits comprising nanoparticle-entrapped dyes.

La présente invention a trait à un système de nanoparticules de grande efficacité pour la stabilisation de colorants fluorescents de proche infrarouge tels que le vert d'indocyanine (ICG) en vue de l'amélioration de l'utilisation du colorant pour une application biomédicale. L'invention a également trait à des nanoparticules comportant des matériaux à base de polymère biodégradable par exemple de l'acide poly(dl-lactique- polyglycolique) (PLGA). L'invention a trait en outre à des procédés de préparation de colorants chargés de nanoparticules, ainsi que des procédés pour leur utilisation en bioimagerie, en diagnostic, et dans le traitement de maladie. Enfin la présente invention a trait à des compositions et des trousses comprenant des colorants chargés de nanoparticules.

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