Nanoparticle-coated capsule formulation for dermal drug...

Details Nanoparticle-coated capsule formulation for dermal drug... Nanoparticle-coated capsule formulation for dermal drug...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2683940

A method and formulation for the delivery of an active substance to the skin (epidermis, including the stratum corneum and viable epidermis, and dermis) of a subject. The formulation comprises oil-based or aqueous droplets comprising the active substance within a coating of nanoparticles, particularly silica nanoparticles. The active substance may be suitable for the treatment of a disease or condition which is localised, or at least partially localised, to the skin (eg skin cancer, psoriasis, eczema, infections including bacterial and fungal infections, acne, dermatitis, inflammation, and rheumatoid arthritis).

L'invention porte sur un procédé et une formulation permettant une administration cutanée (épiderme, c'est-à-dire stratum corneum et épiderme viable, et derme) d'une substance active. La formulation comprend des gouttelettes à base d'huile ou d'eau renfermant la substance active dans un enrobage de nanoparticules, en particulier des nanoparticule de silice. La substance active peut être appropriée pour le traitement d'une maladie ou d'un état localisé, ou au moins partiellement localisé, à la peau (par exemple le cancer de la peau, le psoriasis, l'eczéma, les infections comprenant les infections bactériennes et fongiques, l'acné, la dermatite, l'inflammation et l'arthrite rhumatoïde).

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