Nanoparticle compositions for nucleic acids delivery system

Details Nanoparticle compositions for nucleic acids delivery system Nanoparticle compositions for nucleic acids delivery system

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/28 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2731173

The present invention is directed to nanoparticle compositions for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

La présente invention porte sur des compositions de nanoparticules pour l'administration d'oligonucléotides et sur des procédés de modulation d'une expression d'un gène ciblé à l'aide des compositions de nanoparticules. En particulier, l'invention porte sur des oligonucléotides encapsulés dans un mélange d'un lipide cationique, un lipide fusogénique et un lipide PEG.

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