Nanoparticle conjugates

Details Nanoparticle conjugates Nanoparticle conjugates

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C08G 65/329 (2006.01) G01N 33/543 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2606018

Conjugate compositions are disclosed that include a specific-binding moiety covalently coupled to a nanoparticle through a heterobifunctional polyalkyleneglycol linker. In one embodiment, a conjugates is provided that includes a specific-binding moiety and. a fluorescent nanoparticle coupled by a heterobifunctional PEG linker. Fluorescent conjugates according to the disclosure can provide exceptionally intense and stable signals for immunohistochemical and in situ hybridization assays on tissue sections and cytology samples, and enable multiplexing of such assays.

L'invention concerne des compositions de nanoparticules qui comprennent un fragment à liaison spécifique couplé par covalence à une nanoparticule via un lieur polyalkylèneglycol hétérobifonctionnel. Dans un mode de réalisation, l'invention porte sur un conjugué comprenant un fragment à liaison spécifique et une nanoparticule fluorescente couplée par un linker PEG hétérobifonctionnel. Les conjugués fluorescents de l'invention permettent d'obtenir des signaux exceptionnellement intenses et stables dans les dosages immunohistochimiques et d'hybridation in situ sur des sections de tissus et des prélèvements cytologiques, et permettent le multiplexage desdits dosages.

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