Nanoparticles comprising chitosan and cyclodextrin

Details Nanoparticles comprising chitosan and cyclodextrin Nanoparticles comprising chitosan and cyclodextrin

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 47/36 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2610403

The invention relates to a system comprising nanoparticles for the release of biologically-active molecules, in which the nanoparticles contain: (a) at least 40 wt.- % chitosan or a derivative thereof, and (b) less than 60 wt.- % cyclodextrin or a derivative of same, whereby both components (a and b) are mixed without a covalent bond forming therebetween. The inventive system enables the effective association of biologically-active molecules and the subsequent release thereof in a suitable biological environment.

L'invention concerne un système qui comprend des nanoparticules destinées à la libération de molécules biologiquement actives, ces nanoparticules contenant (a) au moins 40 % en poids de chitosane ou un dérivé de celui-ci et b) moins de 60 % en poids d'une cyclodextrine ou un dérivé de celle-ci, les deux composants (a) et (b) se trouvant mélangés, sans que se forme une union covalente entre eux. Ce système permet une association efficace des molécules biologiquement actives, ainsi que leur libération ultérieure dans un environnement biologique adéquat.

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