Nanoparticles for providing immune responses against...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 33/00 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2652759

Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.

L'invention concerne des nanoparticules destinées à induire des réponses immunitaires pour le traitement ou la prévention d'une infection par des agents infectieux, tels que des virus, des parasites, des bactéries, des prions et des champignons. Ces nanoparticules comprennent un noyau renfermant des atomes de métal et/ou de semi-conducteur, ce noyau étant lié par covalence à une pluralité de ligands, ces ligands renfermant un résidu glucidique permettant de stimuler une réponse immunitaire innée, un peptide auxiliaire de lymphocyte T et un signal de danger. La plateforme peut ensuite être adaptée par inclusion d'un ou plusieurs ligands supplémentaires capables de produire une réponse spécifique à un agent infectieux cible.

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