Nanoparticles for targeted delivery of active agents

Details Nanoparticles for targeted delivery of active agents Nanoparticles for targeted delivery of active agents

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2623293

The present invention concerns a delivery system comprising a polymer-based nanoparticle; and a linker comprising a first portion non-covalently anchored to said nanoparticle, wherein at least part of said first portion comprises a hydrophobic/lipophilic segment embedded in said nanoparticle; and a second portion comprising a maleimide compound exposed at the outer surface of said nanoparticle. In accordance with one embodiment, the delivery system comprises one or more targeting agents, each covalently bound to said maleimide compound. In accordance with yet another embodiment, the delivery system comprises a drug. A specific example for a linker in accordance with the invention is octadecyl-4-(maleimideomethyl)cyclohexane-carboxylic amide (OMCCA).

L'invention concerne un dispositif d'administration comprenant une nanoparticule à base de polymère, et un coupleur comprenant une première partie ancré par une liaison non covalente à ladite nanoparticule, une partie au moins de cette première partie comprenant un segment hydrophobe/lipophile incorporé dans ladite nanoparticule, et une seconde partie comprenant un composé maléimide exposé à la surface externe de ladite nanoparticule. Dans une forme de réalisation, ce dispositif d'administration comprend un ou plusieurs agents de ciblage qui sont chacun couplés de manière covalente au composé maélimide. Dans une forme de réalisation différente, ce dispositif d'administration comprend un médicament. Un exemple spécifique de coupleur selon la présente invention est un coupleur amide octadécyl-4-(maléimideométhyl)cyclohexane-carboxylique (OMCCA).

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