A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) A61P 31/04 (2006.01) C07D 499/00 (2006.01)
Patent
CA 2742650
The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to nanoparticles of said complexes, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least said complex and/or said nanoparticles. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of bacterial infections, in particular caused by strains that are sensitive to beta-lactams.
La présente invention concerne un complexe formé d'au moins une molécule de bêta-lactamine couplée de manière covalente à au moins un radical hydrocarboné comprenant au moins 18 atomes de carbone et contenant au moins une unité 2--méthyl-buta-2-ène, des nanoparticules de ces complexes et leur procédé de préparation, ledit complexe et/ou lesdites nanoparticules étant éventuellement sous la forme d'un lyophilisât. La présente invention vise également une composition pharmaceutique comprenant au moins ledit complexe et/ou lesdites nanoparticules. Elle vise enfin ledit complexe et/ou lesdites nanoparticules pour le traitement et/ou la prévention d'infections bactériennes, notamment dues aux souches sensibles aux béta-lactamines.
Couvreur Patrick
Desmaele Didier
Zouhiri Fatima
Centre National de La Recherche Scientifique
Robic
Universite Paris Sud
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