A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/64 (2006.01)
Patent
CA 2613474
The present invention provides a composition comprising ziprasidone useful in the treatment and prevention of schizophrenia and similar psychiatric disorders. In one embodiment, the composition comprises nanoparticulate particles comprising ziprasidone and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. In another embodiment, the composition comprises a modified release composition that, upon administration to a patient, delivers ziprasidone in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and to methods for the treatment and prevention of schizophrenia and similar psychiatric disorders.
La présente invention concerne une composition comprenant de la ziprasidone utilisée pour le traitement et la prévention de la schizophrénie et de troubles psychiatriques similaires. Dans un mode de réalisation, la composition inclut des nanoparticules comprenant de la ziprasidone et au moins un agent stabilisant de surface. Les nanoparticules ont une taille effective moyenne inférieure à 2000 nm environ. Dans un autre mode de réalisation, la composition comprend une composition de libération modifiée qui, après administration à un patient, délivre la ziprasidone de manière bimodale, multimodale ou continue. L'invention concerne également des formes galéniques contenant de telles compositions et des procédés de traitement et de prévention de la schizophrénie et de troubles psychiatriques similaires.
Devane John G.
Fanning Niall
Jenkins Scott
Liversidge Gary
Rekhi Gurvinder
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Elan Pharma International Limited
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