Nanoparticulate and controlled release compositions...

A - Human Necessities – 61 – K

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Details

A61K 31/546 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2612994

The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a composition which comprises nanoparticulate particles comprising the cefditoren, or a salt, derivative, prodrug, or other form thereof and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. The invention provides also a composition that delivers a cefditoren, or a salt, derivative, prodrug, or other form thereof, or nanoparticles comprising the same, in a pulsatile or continuous manner.

Cette invention concerne une composition comprenant un composé à base de cefditoren (sel, dérivé, promédicament ou autre forme), par exemple du cefditoren pivoxil, utilisée dans le traitement et la prévention des infections et des affections associées. L'invention propose une composition qui contient des nanoparticules renfermant le cefditoren (sel, dérivé, promédicament ou autre forme) et au moins un stabilisant de surface. Les nanoparticules ont une dimension particulaire moyenne effective de moins d'environ 2 000 nm. L'invention propose également une composition qui administre le cefditoren (sel, dérivé, promédicament ou autre forme), ou les nanoparticules renfermant le cefditoren, par impulsion ou en continu.

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