Nanoparticulate and controlled release compositions...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/546 (2006.01) A61K 9/14 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61P 19/10 (2006.01) A61P 31/04 (2006.01) A01N 47/06 (2006.01) A01P 1/00 (2006.01)

Patent

CA 2609296

The present invention is directed to compositions comprising a nanoparticulate antibiotic having improved bioavailability. Preferably, the antibiotic comprises nanoparticulate cephalosporin particles with an effective average particle size of less than about 2000 nm and are useful in the treatment of bacterial infection. The invention also relates to a controlled release composition comprising a cephalosporin or a nanoparticulate cephalosporin that in operation delivers the drug in a pulsed or bimodal manner for the treatment of bacterial infection. The nanoparticulate cephalosporin particles may be formulated as a controlled release drug delivery system whereby the particles are coated one or more times with one or more natural or synthetic hydrophilic or hydrophobic polymer coating materials or dispersed throughout a natural or synthetic hydrophilic and/or hydrophobic polymer matrix.

La présente invention concerne des compositions comprenant des antibiotiques nanoparticulaires possédant une biodisponibilité améliorée. De préférence, l'antibiotique comprend des particules de céphalosporine nanoparticulaire possédant une taille moyenne des particules inférieure à 2000 nm et étant utiles dans le traitement d'infections bactériennes. L'invention concerne aussi une composition à libération contrôlée comprenant une céphalosporine ou une céphalosporine nanoparticulaire qui, pendant le fonctionnement, fournit le médicament de manière pulsée ou bimodale à des fins de traitement d'une infection bactérienne. Les particules de céphalosporine nanoparticulaire peuvent se présenter comme une formulation de médicament à système de libération contrôlée, les particules étant enrobées une ou plusieurs fois avec un ou plusieurs matériaux d'enrobage polymères synthétiques ou naturelles hydrophobes ou hydrophiles ou dispersés via une matrice polymère synthétique ou naturelle hydrophobe et/ou hydrophile.

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