Nanoparticulate aripiprazole formulations

Details Nanoparticulate aripiprazole formulations Nanoparticulate aripiprazole formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2622758

The present invention is directed to compositions and methods comprising nanoparticulate aripiprazole, or salts or derivatives thereof, having improved bioavailability, faster rates of absorption and a faster onset of therapeutic effect. The nanoparticulate aripiprazole compositions are proposed to have an average effective particle size of less than about 2000 nm, and may be useful for the treatment of diseases and disorders of the central nervous system, including mental diseases and disorders.

La présente invention concerne des procédés et compositions à base d'aripiprazole particulaire, ou de certains de leurs sels ou dérivés, se distinguant par une meilleure biodisponibilité, des vitesses d'absorption plus élevées, et un déclenchement plus rapide de l'effet thérapeutique. Les compositions proposées, qui présentent un calibre particulaire moyen réel inférieur à environ 2000 nm, semblent convenir au traitement d'affections et de troubles du système nerveux central, et notamment les affections et troubles mentaux.

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