Nanoparticulate clopidogrel formulations

Details Nanoparticulate clopidogrel formulations Nanoparticulate clopidogrel formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/4365 (2006.01)

Patent

CA 2607494

The present invention is directed to compositions comprising a nanoparticulate clopidogrel, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate clopidogrel particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the prevention and treatment of pathologies induced by platelet aggregation. The clopidogrel particles may also be formulated as a controlled release polymeric coating or matrix drug delivery system.

La présente invention concerne des compositions comprenant des nanoparticules de clopidogrel ou un sel ou dérivé correspondant, à biodisponibilité améliorée. Les nanoparticules de clopidogrel de cette composition ont une taille de particule moyenne effective de moins de 2000 nm et sont utiles dans la prévention et le traitement de pathologies induites par agglomération de lamelles. Ces particules de clopidogrel peuvent aussi être formulées comme enrobage polymérique à libération contrôlée ou système matriciel d~administration de médicament.

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