Nanoparticulate compositions comprising amorphous...

Details Nanoparticulate compositions comprising amorphous... Nanoparticulate compositions comprising amorphous...

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2384670

Nanoparticulate amorphous cyclosporine formulations, and nanoparticulate cyclosporine formulations comprising a mixture of amorphous and crystalline cyclosporine, having effective average particle sizes of less than about 2000 nm are described. The compositions exhibit increased bioavailability and increased consistency of bioavailability as compared to prior macro-sized cyclosporine and formulations. Methods of making and using the compositions are also described.

L'invention concerne des formulations de cyclosporine amorphe à nanoparticules ainsi que des formulations de cyclosporine à nanoparticules comportant un mélange de cyclosporine cristalline et amorphe, possédant des tailles de particules moyennes efficaces, inférieures à 2000 nm environ. Ces compositions présentent une biodisponibilité augmentée et une consistence accrue de biodisponibilité, si on les compare aux précédentes formulations de cyclosporine à taille macro. L'invention concerne également des procédés de fabrication et d'utilisation de ces mêmes compositions.

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