Nanoparticulate kinase inhibitor formulations

Details Nanoparticulate kinase inhibitor formulations Nanoparticulate kinase inhibitor formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2654909

The invention is directed to compositions comprising at least one nanop articulate kinase inhibitor, such as LS 104 or a salt or derivative thereof, having improved dissolution rate providing a faster onset of drug availability. The nanoparticulate kinase inhibitor particles, such as LS 104, have an effective average particle size of less than about 2000 nm and are useful in the treatment of cancers, such as leukemia, myeloproliferative disorders and related diseases.

La présente invention concerne des compositions contenant au moins un inhibiteur de kinase nanoparticulaire, tel que le LS 104 ou son sel ou son dérivé, présentant une vitesse de dissolution améliorée qui conduit à une mise à disponibilité du médicament plus rapide. Les particules de l'inhibiteur de kinase nanoparticulaire, tel que le LS 104, ont une dimension moyenne efficace inférieure à environ 2000 nm et elles se révèlent utiles pour le traitement de cancers, tels qu'une leucémie, des troubles myéloproliférants et des maladies associées.

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