A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/10 (2006.01) A61B 5/055 (2006.01) A61K 49/00 (2006.01) C09B 47/04 (2006.01)
Patent
CA 2541385
A new class of micro- and nano- particulate paramagnetic spin probes especially useful for magnetic resonance imaging techinques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
La présente invention concerne une nouvelle classe de sonde de spin paramagnétique microparticulaire et nanoparticulaire qui convient en particulier pour des techniques d'imagerie par résonance magnétique, comprenant une imagerie par résonance paramagnétique électronique (EPR) et par résonance magnétique (IRM). Ces sondes sont des dérivés phthalocyanine de lithium. Cette mention concerne aussi des suspensions et des émulsions comprenant des sondes de dérivés de phthalocyanine de lithium. Cette invention concerne aussi des techniques non invasives permettant de mesurer par des techniques de mesure non invasives la concentration d'oxygène, la pression partielle d'oxygène, le métabolisme oxygène et la concentration d'oxyde nitrique dans un tissu, un organe ou une cellule in vivo ou in vitro spécifique.
Kuppusamy Periannan
Pandian Ramasamy P.
Parinandi Narasimham L.
Zweier Jay L.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Ohio State University Research Foundation
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