Nanosecond pulsed electric fields cause melanomas to...

A - Human Necessities – 61 – N

Patent

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A61N 1/00 (2006.01)

Patent

CA 2643210

Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields ("nsPEFs") are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.

L'invention concerne des méthodes pour une nouvelle thérapie sans médicament pour traiter des tumeurs solides de la peau par l'application de champs électriques pulsés en nanosecondes (nsPEF). Dans un mode de réalisation de l'invention, les cellules sont des cellules de mélanome, et les nsPEF appliqués pénètrent à l'intérieur de cellules tumorales et causent un rétrécissement rapide des noyaux des cellules tumorales et l'arrêt du flux sanguin tumoral. Cette nouvelle technique permet de viser des cellules tumorales très localisées avec seulement des effets mineurs sur la peau sus-jascente.

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