A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/72 (2006.01) A61K 9/14 (2006.01) A61K 31/415 (2006.01) A61K 31/4174 (2006.01) A61K 31/4196 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2716658
The present invention is directed to new nanosuspensions of antifungal azole derivatives, particularly itraconazole, with improved impurity profile optimized for inhaled administration for the prevention, reversal and medical treatment of fungal infections of the respiratory tract including adjacent lymph nodes. The new formulation which is devoid of particulate inorganic contamination can be safely administered by inhalation. This administration route results in an improved therapeutic effect and reduced side effect profile as compared to the previously used clinical administration route, i.e. oral or parenteral (intravenous) administration.
La présente invention concerne de nouvelles nanosuspensions de dérivés azoles antifongiques, particulièrement l'itraconazole, présentant un profil d'impuretés optimisé pour une administration par inhalation pour la prévention, l'inversion ou le traitement médical d'infections fongiques des voies respiratoires y compris les ganglions lymphatiques adjacents. La nouvelle formulation qui est dépourvue de contamination inorganique particulaire peut être administrée sans risque par inhalation. Cette voie d'administration entraîne une amélioration de l'effet thérapeutique par comparaison à la voie d'administration clinique utilisée auparavant, c'est-à-dire, l'administration orale ou parentérale (intraveineuse).
Rundfeldt Chris
Scherliess Holger
Schlichthaar Rainer
Steckel Hartwig
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schlichthaar Rainer
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