Nanotherapeutic colloidal metal compositions and methods

Details Nanotherapeutic colloidal metal compositions and methods Nanotherapeutic colloidal metal compositions and methods

A - Human Necessities

61

K

A61K 47/48 (2006.01) B82Y 5/00 (2011.01) A61K 9/14 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2700378

The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, the nanotherapeutic compositions of the present invention comprise a platform comprising a colloidal metal, a targeting ligand such a tumor necrosis factor, a stealth agent such as polyethylene glycol, and one or more diagnostic or therapeutic agents for delivery. The invention also comprises methods and compositions for making such nanotherapeutic compositions and for the treatment of cancer.

La présente invention concerne des compositions et des procédés pour des modes d'administration d'agents, comprenant des composés thérapeutiques, des agents pharmaceutiques, des médicaments, des agents de détection, des séquences d'acide nucléique et des facteurs biologiques. En général, les compositions nanothérapeutiques de la présente invention comprennent une plateforme comprenant un métal colloïdal, un ligand de ciblage comme un facteur de nécrose tumorale, un agent furtif comme du polyéthylène glycol, et un ou plusieurs agents de diagnostic ou thérapeutiques pour l'administration. L'invention comprend également des procédés et des compositions pour fabriquer de telles compositions thérapeutiques et pour le traitement du cancer.

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