Naphthalene-1,5-disulfonic acid salts of a substituted...

Details Naphthalene-1,5-disulfonic acid salts of a substituted... Naphthalene-1,5-disulfonic acid salts of a substituted...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01)

Patent

CA 2543012

This invention provides naphthalene-1,5-disulfonic acid salts of 4-{N-[7-(3- (S)-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl]-N- (isopropyl)amino}-1-(4-methoxypyrid-3-ylmethyl)piperidine, which salts are useful as muscarinic receptor antagonists. This invention is also directed to pharmaceutical compositions comprising these salt forms, methods of using these salt forms for treating medical conditions mediated by muscarinic receptors; and processes for preparing these salt forms.

L'invention concerne des sels d'acide naphtalène-1,5-disulfonique de 4-{<I>N</I>-[7-(3-(<I>S</I>)-1-carbamoyl-1,1-diphénylméthyl)pyrrolidin-1-yl)hept-1-yl]-<I>N</I>-(isopropyl)amino}-1-(4-méthoxypyrid-3-ylméthyl)pipéridine, ces sels pouvant être utilisés en tant qu'antagonistes des récepteurs muscariniques. Cette invention se rapporte en outre à des compositions pharmaceutiques contenant ces formes salines, à des procédés d'utilisation de ces formes salines pour traiter des états médicaux dont la médiation est assurée par les récepteurs muscariniques, ainsi qu'à des procédés pour préparer lesdites formes salines.

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