Naphthalene and quinoline sulfonylurea derivatives as ep4...

Details Naphthalene and quinoline sulfonylurea derivatives as ep4... Naphthalene and quinoline sulfonylurea derivatives as ep4...

C - Chemistry, Metallurgy

07

D

C07D 209/64 (2006.01) A61K 31/4035 (2006.01) A61K 31/4745 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2681146

The invention is directed to naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.

L'invention porte sur des dérivés de naphtalène et quinoléine sulfonylurée en tant qu'antagoniste du récepteur EP4, utiles pour le traitement de maladies ou états à médiation par EP4, telles que la douleur aiguë et chronique, l'ostéoarthrite, l'arthrite rhumatoïde et le cancer. L'invention porte également sur des compositions pharmaceutiques et des procédés d'utilisation.

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