Naphthalene anti-psoriatic agents

Details Naphthalene anti-psoriatic agents Naphthalene anti-psoriatic agents

C - Chemistry, Metallurgy

07

C

167/255, 260/489

C07C 69/035 (2006.01) A61K 31/215 (2006.01) C07C 45/63 (2006.01) C07C 46/00 (2006.01) C07C 46/02 (2006.01) C07C 50/24 (2006.01) C07C 50/32 (2006.01) C07C 205/48 (2006.01) C07C 323/21 (2006.01) C07D 213/70 (2006.01) C07D 213/89 (2006.01)

Patent

CA 1285575

ABSTRACT OF THE DISCLOSURE Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: Image (I) wherein: R1 and R2 are lower alkoxy or lower alkylthio; R3 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(O)nR wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms.

439770

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