Naphthalene-based inhibitors of anti-apoptotic proteins

Details Naphthalene-based inhibitors of anti-apoptotic proteins Naphthalene-based inhibitors of anti-apoptotic proteins

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) A61K 31/045 (2006.01) A61K 31/12 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 49/83 (2006.01) C07C 235/66 (2006.01)

Patent

CA 2703724

Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X5 SO2NHX, and NHSO2X5 wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

L'invention concerne des procédés d'utilisation d'apogossypol et de ses dérivés pour le traitement d'une inflammation. Elle concerne également un groupe de composés possédant la structure A, ou un sel, hydrate, N-oxyde ou solvate pharmaceutiquement acceptable de ces composés; où chaque R est indépendamment choisi dans le groupe constitué par H, C(O)X, C(O)NHX, NH(CO)X5 SO2NHX, et NHSO2X5 où X est choisi dans le groupe constitué par un alkyle, un alkyle substitué, un aryle, un aryle substitué, un alkylaryle et un hétérocycle. Les composés du groupe A peuvent être utilisés pour traiter diverses maladies ou divers troubles tels que le cancer.

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