Naphthalene-based inhibitors of anti-apoptotic proteins

Details Naphthalene-based inhibitors of anti-apoptotic proteins Naphthalene-based inhibitors of anti-apoptotic proteins

C - Chemistry, Metallurgy

07

C

C07C 235/66 (2006.01) A61K 31/166 (2006.01)

Patent

CA 2758491

Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

Cette invention concerne des méthodes d'utilisation de l'apogossypol et de ses dérivés pour traiter l'inflammation. L'invention concerne également un groupe de composés de structure A, ou un sel, hydrate, N-oxyde ou solvate pharmaceutiquement acceptable : chaque R étant indépendamment H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, ou NHSO2X, X étant hydrogène, alkyle, alkyle substitué, aryle, aryle substitué, alkylaryle, alkylaryle substitué, hétérocycle, ou hétérocycle substitué. Les composés du groupe A peuvent être utilisés pour traiter différentes maladies ou pathologies, comme le cancer.

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