Naphthalene carboxamides and their derivatives useful as new...

Details Naphthalene carboxamides and their derivatives useful as new... Naphthalene carboxamides and their derivatives useful as new...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 213/68 (2006.01) C07D 215/20 (2006.01) C07D 239/34 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2536788

The invention relates to compounds represented by Formula (I) and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of R1a-d , R2a-b , R3, and X1 are defined herein, The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula(l).

L'invention concerne des composés représentés par la formule (I) et leurs pro-médicaments, les sels ou solvates pharmaceutiquement acceptables de ces composés ou de ces pro-médicaments, ainsi que des compositions pharmaceutiques qui contiennent les composés de formule (I) et des méthodes de traitement de troubles hyperprolifératifs chez des mammifères par administration des composés de formule (I). Dans la formule, R?1a-d¿, R?2a-b¿, R?3¿ et X?1¿ ont la définition donnée dans la demande.

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