Naphthalene carboxylic acids

Details Naphthalene carboxylic acids Naphthalene carboxylic acids

C - Chemistry, Metallurgy

07

C

167/254, 167/262

C07C 59/66 (2006.01) A61K 31/19 (2006.01) C07C 59/68 (2006.01) C07C 59/90 (2006.01) C07C 65/24 (2006.01) C07C 65/40 (2006.01)

Patent

CA 2004696

RAN 4070/75 Abstract Naphthalene carboxylic acid derivatives of the formula Image I wherein one of R1 and R2 is -(CHR10)m-C(O)OR, and the other is hydrogen, wherein R is hydrogen or lower alkyl, R10 is hydrogen or lower alkyl, and m is 0 or 1 A is Image A' wherein R3 is hydrogen or acyl, R4 is hydrogen, halogen, lower alkyl, aryl or cycloalkyl, R5 and R6 independently are hydrogen or halogen, and n is an integer from 2-10, or A is Image A" wherein R3 is hydrogen or acyl, R7 is hydrogen or lower alkyl, R8 and R9, independently, are hydrogen, lower alkyl or halogen, t is 0 or 1. and n is an integer from 2-10, and, when R10 is lower alkyl, enantiomers and racemates thereof, and, when R is hydrogen, salts thereof with pharmaceutically acceptable bases are useful as antiinflammatory agents.

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