Naphthalene derivatives

Details Naphthalene derivatives Naphthalene derivatives

C - Chemistry, Metallurgy

07

C

C07C 49/84 (2006.01) A61K 31/12 (2006.01) A61P 29/00 (2006.01) C07C 45/71 (2006.01)

Patent

CA 2427844

The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2NH, P(O)OCH3, P(O)OH, NH, N(CH3), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH2NH, C(=NH); R1 is aryl or heteroaryl; R2 is hydrogen, OR4 or NR5R6 and the other variables are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals in treating or preventing a disease or condition in which cannobinoid receptor activation plays a rôle or is implicated. (I)

L'invention concerne de nouveaux dérivés de naphtalène de la formule (I). R?1¿, R?2¿, R?3¿ et X sont tels que définis dans le descriptif. Elle concerne également leur préparation. Les composés de la formule (I) sont utiles en tant que produits pharmaceutiques.

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