Naphthalene derivatives

Details Naphthalene derivatives Naphthalene derivatives

C - Chemistry, Metallurgy

07

D

260/267.1, 260/2

C07D 295/00 (2006.01) C07D 295/096 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07D 295/26 (2006.01)

Patent

CA 1101858

A B S T R A C T A process for preparing a compound corresponding to the formula Image in which R' is a hydrogen atom or a methyl radical and R represents a radical Image , in which Z is O, S, S? O, SO2 or NR1, in which R1 is a hydrogen atom or an alkyl, CONR2R3, COOR2, COR2 or SO2R2 radical, R2 and R3 each representing, independently of one another, a hydrogen atom, an alkyl radical having 1 to 4 carbon atoms, a phenyl radical or a CF3 radical, in the form of racemates or enantiomers when R' is CH3, and also where appropiate, their addition salts with pharmaceutically acceptable acids, in which process (a) an acid halide of formula Image (II) is reacted with the appropriate heterocyclic amine RH (III) and the resulting intermediate of the formula Image (IV) is then reduced to produce the compound (I) or its salt; or (b) a mesylate of fromula Image (v), obtained by reacting the corresponding naphthalene alcohol with a methylsulphonl halide, is reacted with the amine RH (III) to produce the compound (I) or its salt, R and R' having the meanings given above; or (c) a compound (I) or its salt is converted, if desired and appropriate, to another compound (I) or salt by means known per se. The compounds (I) and their salts are useful as anti-inflammatory agents, e.g. for treating arthritis.

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