Naphthalene derivatives

Details Naphthalene derivatives Naphthalene derivatives

C - Chemistry, Metallurgy

07

C

C07C 59/64 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 39/40 (2006.01) C07C 43/20 (2006.01) C07C 43/23 (2006.01) C07C 43/253 (2006.01) C07C 45/00 (2006.01) C07C 47/575 (2006.01) C07C 59/52 (2006.01) C07C 59/72 (2006.01) C07C 59/90 (2006.01) C07C 69/73 (2006.01) C07C 69/734 (2006.01) C07C 69/738 (2006.01) C07C 235/34 (2006.01) C07C 251/48 (2006.01) C07C 255/41 (2006.01) C07D 213/75 (2006.01) C07D 295/185 (2006.01) C07D 307/52 (2006.01)

Patent

CA 2055630

ABSTRACT OF THE DISCLOSURE Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: Image (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: Image (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: Image (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: Image (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group).

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