Naphthalene derivatives

Details Naphthalene derivatives Naphthalene derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/56 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/245 (2006.01) A61K 31/275 (2006.01) A61K 31/41 (2006.01) C07C 233/11 (2006.01) C07C 233/22 (2006.01) C07C 233/53 (2006.01) C07C 233/55 (2006.01) C07C 233/65 (2006.01) C07C 233/75 (2006.01) C07C 233/81 (2006.01) C07C 235/38 (2006.01) C07C 235/42 (2006.01) C07C 235/64 (2006.01) C07C 235/84 (2006.01) C07C 237/20 (2006.01) C07C 237/44 (2006.01) C07C 255/60 (2006.01) C07C 311/46 (2006.01) C07C 323/29 (2006.01) C07C 323/42 (2006.01) C07C 323

Patent

CA 2190992

Naphthalene derivatives represented by formula [I]: Image (wherein A is a hydrogen atom, a hydroxy group, a C1-C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1-C12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the alkyl may be substituted with a C6-C10 allyloxy group; B represents O, S, CH2, O-C2, S-CH2, CO, or CHOR1 C represents CO, CR2R1CO, CH2CH2CO, or CH=CHCO; D represents a hydrogen atom, NO2, NH2, CO2R4, or a group having the following. formula [II]: Image (wherein G represents a hydrogen atom, OH, SO2NH2, CO2R6, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO2NH, CO2R5, CN, or a tetrazol-5-yl group; F represents a hydrogen atom, a C1-C4 lower alkyl group, a nitro group , or a halogen atom; and R1, R3, R3, R4, R'5 and R6 are, independently each other, a hydrogen atom or a C1-C4 lower alkyl group); pharmacologically acceptable salts thereof, or pharmacologically acceptable solvates thereof, which have, for example, an inhibitory effect on the production of IgE antibodies, and will be useful for prophylaxis and/or treatment of allergic diseases.

L'invention concerne un dérivé de naphthalène représenté par la formule générale (I), un sel médicalement acceptable de ce dérivé, ou bien un solvate médicalement acceptable de ce dérivé ou de ce sel. Dans ladite formule (I), A représente hydrogène, hydroxy, alcoxy, etc.; B représente O, S, CO, etc.; C représente CO, CH2CH2CO, etc.; D représente hydrogène, NO2, NH2, etc.; E représente hydrogène, OH, SO2NH2, etc.; et F représente hydrogène, alkyle inférieur, etc. Un tel dérivé, un sel médicalement acceptable de celui-ci, ou un solvate médicalement acceptable de ce dérivé ou de ce sel ont, par exemple, un effet inhibant la production d'anticorps IgE et peuvent être utilisés, par exemple, pour prévenir et/ou soigner des maladies allergiques.

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