Naphthalene derivatives as prostaglandin 12 agonists

Details Naphthalene derivatives as prostaglandin 12 agonists Naphthalene derivatives as prostaglandin 12 agonists

C - Chemistry, Metallurgy

07

C

C07C 271/28 (2006.01) A61K 31/27 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/695 (2006.01) C07C 271/12 (2006.01) C07C 271/38 (2006.01) C07C 281/02 (2006.01) C07D 213/64 (2006.01) C07D 237/14 (2006.01) C07D 303/16 (2006.01) C07D 405/02 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2185104

A compound of formula (I) wherein, R1 is carboxy or protected carboxy: R2 is hydrogen, hydroxy or protected hydroxy; R3 is hydrogen, hydroxy, protected hydroxy, etc.; R4 is hydrogen or halogen; A1 is lower alkylene; A2 is bond or lower alkylene; -R5 is (a) (in which R6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc; and (b) is (c), etc.; and a pharmaceutically acceptable salt thereof which are useful as medicaments.

La présente invention concerne un composé de formule (I) et l'un de ses sels pharmaceutiquement acceptables qui sont utiles comme médicaments. Dans cette formule (I), R<1> représente carboxy ou carboxy protégé; R<2> représente hydrogène, hydroxy ou hydroxy protégé; R<3> représente hydrogène, hydroxy, hydroxy protégé, etc.; R<4> représente hydrogène ou halogène; A<1> représente alkylène inférieur; A<2> représente une liaison ou alkylène inférieur; -R<5> a la formule (a). Dans cette formule (a), R<6> représente alkyle (inférieur ou non) de mono (di ou tri)aryle; et Z représente N ou CH, etc. et (b) représente (c), etc.

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