Naphthalenecarboxamides as tachykinin receptor antagonists

Details Naphthalenecarboxamides as tachykinin receptor antagonists Naphthalenecarboxamides as tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/24 (2006.01) A61K 31/445 (2006.01) C07C 235/66 (2006.01) C07C 255/57 (2006.01) C07D 211/20 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 401/04 (2006.01) C07D 413/10 (2006.01) C07D 417/12 (2006.01) C07F 9/59 (2006.01)

Patent

CA 2345133

A compound having formula (I) wherein R1 is oxo, -ORa, -OC(=O)Rb; or (A); R2 is H; or R1 is -ORc and R2 is -ORd; or R1 and R2 together form -O(CH2)mO-; and any pharmaceutically-acceptable salt thereof along with their use in treating depression, anxiety, asthma, rheumatoid arthritis, Alzheimer's disease, cancer, schizophrenia, oedema, allergic rhinitis, inflammation, pain, gastrointestinal-hypermotility, anxiety, emesis, Huntington's disease, psychoses including depression, hypertension, migraine, bladder hypermotility, or urticaria, along with methods of making the compounds and pharmaceutical compositions containing the compounds.

L'invention se rapporte à un composé représenté par la formule (I) dans laquelle R?1¿ est oxo, -OR?a¿, -OC(=O)R?b¿; ou par la formule (A) dans laquelle R?2¿ est H; ou R?1¿ est -OR?c¿ et R?2¿ est -OR?d¿; ou R?1¿ et R?2¿ forment ensemble -O(CH¿2?)¿m?O-. L'invention se rapporte également à tout sel pharmaceutiquement acceptable de ce composé ainsi qu'à leur utilisation pour traiter la dépression, l'anxiété, l'asthme, la polyarthrite rhumatoïde, la maladie d'Alzheimer, le cancer, la schizophrénie, les oedèmes, la rhinite allergique, les inflammations, la douleur, l'hypermotilité gastro-intestinale, l'anxiété, les vomissements, la chorée de Huntington, les psychoses du type dépression, hypertension, migraine, hypermotilité de la vessie ou l'urticaire. L'invention se rapporte également à des procédés de fabrication de ces composés et des compositions pharmaceutiques contenant ces composés.

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