C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/289, 260/314
C07C 59/66 (2006.01) C07D 213/55 (2006.01) C07D 215/14 (2006.01)
Patent
CA 1330999
NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS Abstract of the Disclosure There are disclosed compounds of the formula Image wherein X is N or CR; Z is Image , Image , Image , Image , S or O; R is hydrogen or lower alkyl; R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.
573481
Bicksler James J.
Giberson John W.
Kreft Anthony F. III
Musser John H.
American Home Products Corporation
Ridout & Maybee Llp
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