Naphthalenepropionic acid derivatives as...

Details Naphthalenepropionic acid derivatives as... Naphthalenepropionic acid derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) A61K 31/19 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) C07C 59/68 (2006.01) C07D 213/30 (2006.01) C07D 213/56 (2006.01) C07D 215/18 (2006.01) C07D 235/08 (2006.01) C07D 235/12 (2006.01) C07D 263/56 (2006.01) C07D 277/24 (2006.01) C07D 277/30 (2006.01) C07D 277/64 (2006.01)

Patent

CA 2089262

2089262 9204325 PCTABS00011 There are disclosed compounds of formula (I), wherein A is alkyl of 3-19 carbon atoms, diloweralkyl vinyl, dihalovinyl, diphenylvinyl, lower alkynyl, (a) or (b); W is -CR2O-, -CH=CH- or -CH=CHCH2O-, X is N or CR; Z is (c), (d), (e), (f), -S- or -O-; R is hydrogen or lower alkyl; Y is (g), (h), (i), (j) or (k), with the proviso that when (g) is (l), R3 is other than OR when W is CH2O; R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring, optionally substituted by halo; R3 is -OR, (m) or -NHSO2R4; R4 is phenyl or loweralkyl substituted phenyl; R5 is hydrogen or halo; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.

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