Naphthalimide dosing by n-acetyl transferase genotyping

Details Naphthalimide dosing by n-acetyl transferase genotyping Naphthalimide dosing by n-acetyl transferase genotyping

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2554775

The present invention provides methods for dosing patients with naphthalimides, including amonafide, amonafide salts, and analogs thereof based on N-acetyl transferase genotyping. The invention also provides methods for dosing the amount of granulocyte colony stimulating factor (GCSF) used in combination with naphthalimide to prevent or modulate leukocytopenia.

La présente invention concerne des techniques permettant d'effectuer des dosages de naphthalimide chez des patients qui comprennent de l'amonafide, des sels d'amonafide et des analogues de ceux-ci basées sur le génotypage de N-acétyle transférase. Cette invention concerne aussi des techniques permettant de doser la quantité de facteur de stimulation de colonies de granulocytes (GCSF) utilisé en combinaison avec la naphthalimide de façon à empêcher ou moduler la leucocytopénie. .

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