Naphthalimidobenzamide derivatives

Details Naphthalimidobenzamide derivatives Naphthalimidobenzamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 221/14 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2300069

The present invention relates to a naphthalimidobenzamide derivative represented by the following formula (1): (see formula 1) (wherein, R1 represents a hydrogen atom, etc., Y represents a hydrogen atom or -CON(R4)-A2-X2, R2 and R4 are the same or different and each independently represents a hydrogen atom, etc., A1 and A2 are the same or different and each independently represents an alkylene group which may be interrupted at least once by -N(R3)- (R3 representing a hydrogen atom, etc.) and X1 and X2 are the same or different and each independently represents a (hetero)aryl group which may have a substituent, etc.) or salt thereof; and a pharmaceutical comprising it as an effective ingredient. The compound is useful as an antitumor agent and the like.

L'invention concerne des dérivés de naphtalimidobenzamide correspondant à la formule générale suivante (1) ou leurs sels ainsi que des médicaments dont les principes actifs contiennent ces sels et dérivés. Dans cette formule, R<1> est hydrogène ou similaire; Y est hydrogène ou -CON(R<4>)-A<2>-X<2>; R<2> et R<4> sont chacun indépendamment hydrogène ou similaire; A<1> et A<2> sont chacun indépendamment alkylène, qui peut être interrompu dans une ou plusieurs positions par -N(R<3>)- (dans lequel R<3> est hydrogène ou similaire) et X<1> et X<2> sont chacun indépendamment (hétéro)aryle éventuellement substitué ou similaire. Ces composés sont utiles en tant qu'agents anti-tumoraux ou similaires.

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