C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/09 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07C 235/66 (2006.01) C07C 255/60 (2006.01) C07C 317/50 (2006.01) C07C 323/63 (2006.01) C07D 211/58 (2006.01) C07D 265/30 (2006.01) C07D 295/13 (2006.01)
Patent
CA 2081147
ABSTRACT New naphthamide derivatives, process for preparing them and their application in the therapeutic field The new naphthamide derivatives according to the invention are characterised in that they correspond to the general formula (I), Image (I) whera X: represents either a hydroqen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphur-containing group such as thiocyanate, alkylthio, alkylsulphinyl or alkylsulphonyl, or a methoxy group, or a nitro group, or a cyano group, or an electron-attracting group; Y : represonts an alkyl or alkenyl residue; Z : represents the residues originating from 2-amino- methyl-N alkylpyrrolidine, 2-aminoethyl-N,N-diethylamine, 2-(aminoethyl)morpholine, 2-aminoethyl-N,N-dibutylamine, 4-amino-N-butylpiperidine or 2-aminoethyl)pyrrolidine; R : a hydrogen or an OCH3 substituent. These new derivatives may be employed in the preparation of medicinal products intended for use as an antipsychotic, psychostimulatory, anti-autistic or antidepressant agent, an agent for treating Parkinson's disease or an antihypertensive agent.
Garrido Fabrice
Giros Bruno
Lecomte Jeanne-Marie
Mann Andre
Martres Marie-Pascale
Institut National de La Sante Et de La Recherche Medicale
Societe Civile Bioprojet
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