C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/66 (2006.01) A61K 31/167 (2006.01) A61K 31/235 (2006.01) A61P 35/00 (2006.01) C07C 237/48 (2006.01)
Patent
CA 2740970
A compound (particularly useful for inhibiting cancer) according to formula (I): or a pharmaceutically acceptable salt thereof, wherein: x is 0 or 1; R1-R6 are each independently H, -CN, -NO2, -NO, -OH, halogen, hydroxyalkyl, carboxyl, substituted carboxyl, aminocarbonyl, alkoxy, carbonyl or substituted carbonyl; R7 is H, alkyl, alkyl amino, aminoacyl, hydroxyacyl, heteroaryl, heterocycloalkyi, alkyl heteroaryl or alkyl heterocycloalkyl; R8 is H or alkyl; A is O or N; and Ar is an aryl, substituted aryl, heteroaryl, or substituted heleroaryl, provided that if R7 is H then Ar is aryl substituted with alkyl amino.
La présente invention concerne un composé de formule (I)) (notamment utile pour inhiber le cancer) : ou un sel pharmaceutiquement acceptable de celui-si : dans laquelle x est 0 ou 1 ; R1-R6 sont chacun indépendamment H, -CN, -NO2, -NO, -OH, halogène, hydroxyalkyle, carboxyle, carboxyle substitué, aminocarbonyle, alcoxy, carbonyle ou carbonyle substitué; R7 est H, alkyle, alkylamino, aminoacyle, hydroxyacyle, hétéroaryle, hétérocycloalkyle, alkyle hétéroaryle ou alkyle hétérocycloalkyle; R8 est H ou alkyle; A est O ou N; et Ar est un aryle, aryle substitué, hétéroaryle, ou hétéroaryle substitué, à condition que si R7 est H alors Ar est aryle substitué avec alkylamino.
Li Bingbing
Xiao Xiangshu
Oregon Health & Science University
Smart & Biggar
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