C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277, 260/300
C07D 235/02 (2006.01) C07D 263/60 (2006.01) C07D 403/06 (2006.01)
Patent
CA 1165762
ABSTRACT Naphth[1,2-d]imidazoles and naphth[2,1-d]oxazoles of formula Image wherein R and R1 are hydrogen, halogen, alkyl or alkoxy, R2 stands for hydrogen or halogen and A represents one of the following moieties Image Image Image (a) (b) (c) wherein R3 represents alkyl, cycloalkyl, or 8 -(CH2)nNR5R6 group in which n is 1,2, or 3, R5 stands for hydrogen or alkyl, R6 is alkyl or R5 and R6 taken to- gether with the adjacent nitrogen atom may represent a 4 to 7 membered saturatedhetero-ring which may contain a further hetero atom and optionally be sub- stituted e.g. with phenyl and substituted phenyl, R4 stands for hydrogen, alkyl,cycloalkyl or a -(CH2)nNR5R6 group provided that one of R3 and R4 is a -(CH2)n- -NR5R6 group, and R7 is -(CH2)n-NR5R6, and their pharmaceutically acceptable acid addition salts are made e.g. by contacting the corresponding naphth[1,2-d] -imidazoles or naphth[2,1-d]oxazoles wherein one of R3 and R4 or R7 is a -( CH2)nX group where X stands for the residue of a reactive ester with the pro-per amine of formula HNR5R6 in the presence of an acid acceptor agent. The new compounds are useful as CNS depressant agents.
370348
Omodei Sale' Amedeo
Toia Emilio
Gruppo Lepetit S.p.a.
Smart & Biggar
LandOfFree
Naphthimidazole and naphthoxazole derivatives their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naphthimidazole and naphthoxazole derivatives their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphthimidazole and naphthoxazole derivatives their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-136386