Naphthoic acid derivative

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/33 (2006.01) C07D 211/46 (2006.01) C07D 211/54 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/38 (2006.01) C07D 213/56 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 307/38 (2006.01) C07D 317/56 (2006.01) C07D 333/18 (2006.01) C07D 333/24 (2006.01) C07D 333/28 (2006.01) C07D 401/10 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2056662

A naphthoic acid derivative represented by the following general formula or a salt thereof: Image wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group: R4 is a hydrogen atom or a lower alkyl group; R5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group; X is a group Image , a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group Image , -R8-NH- or -NH-R8-, where R6 and R7 are each a hydrogen atom or a lower alkyl group and R8 is a cycloalkylene group, or R6 and R7, together with R4, may form an alkylene group of 1-3 carbon atoms; Y is -S(O)p-, -(CH2)n- , -O-, Z is a substituted or unsubstituted alkylene group or a single bond; l is an integer of 0-4; m is an integer of 0-8; n is 0 or 1; p is an integer of 0-2; and q is 0 or 1. The compound is useful as an antiallergic agent.

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